Equine
Gentamicina 8% Hampton
ANTIMICROBIAL/ANTIBIOTIC - AMINOGLYCOSIDE
Bottle x 100 and 250 ml
Formula:
Each ml contains: Gentamicin Sulfate 8 g.; Sterile vehicle q.s. 100 ml
Indications:
Infectious processes caused by sensitive germs. Septicemia, Metritis, Infectious bronchitis, Pneumonia, Urinary infections. Infected wounds.
Administration:
Intramuscular, intravenous and intrauterine route.
Dosage:
Horses: 4 mg/kg every 24 hours for three to five days, or 10 mg/kg every 24 hours for three to five days. For intrauterine infusion, 1 to 3 g per day of Gentamicin, diluted to a volume of 250 ml with warm saline solution for 7 days.
Precautions:
Use with caution (preferably with serum monitoring) in neonatal or geriatric patients. Other risk factors to consider due to the toxicity of Gentamicin are generalized sepsis or severe dehydration of the patient. Prolonged treatments are characterized by the appearance of nephrotoxicity and ototoxicity. Neuromuscular paralysis phenomena have also been described, particularly when administered together with other drugs that affect this system, such as anesthetics and muscle relaxants. These effects depend on the specific aminoglycoside being administered, the drug's blood concentration and peak level, duration of therapy, hydration status, and kidney function prior to treatment. Toxicity phenomena are rare in therapies lasting less than 7 days. Toxicity results from inhibition of phospholipid synthesis (inhibiting the incorporation of phosphate groups) and blockage of various calmodulins. Nephrotoxicosis will be preceded by an increase in blood urea nitrogen and serum creatinine, polyuria, proteinuria or cylindruria. When the eighth cranial nerve is affected, vestibular syndrome or nerve deafness may be seen, depending on the portion affected. This phenomenon can be reversible upon discontinuation of treatment. Gentamicin is highly nephrotoxic and comparatively less ototoxic. Cats are particularly sensitive to aminoglycoside-induced ototoxicity.
Contraindications:
Do not use in animals with a history of hypersensitivity to the drug or renal insufficiency. Do not mix with chloramphenicol as it antagonizes GENTAMICIN. Do not combine with other nephrotoxic agents or diuretics such as furosemide or ethacrynic acid. Do not use concomitantly with muscle relaxants or during anesthesia with halothane or methoxyflurane. Do not apply to horses intended for human consumption.
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Formula:
Each ml contains: Gentamicin Sulfate 8 g.; Sterile vehicle q.s. 100 ml
Indications:
Infectious processes caused by sensitive germs. Septicemia, Metritis, Infectious bronchitis, Pneumonia, Urinary infections. Infected wounds.
Administration:
Intramuscular, intravenous and intrauterine route.
Dosage:
Horses: 4 mg/kg every 24 hours for three to five days, or 10 mg/kg every 24 hours for three to five days. For intrauterine infusion, 1 to 3 g per day of Gentamicin, diluted to a volume of 250 ml with warm saline solution for 7 days.
Precautions:
Use with caution (preferably with serum monitoring) in neonatal or geriatric patients. Other risk factors to consider due to the toxicity of Gentamicin are generalized sepsis or severe dehydration of the patient. Prolonged treatments are characterized by the appearance of nephrotoxicity and ototoxicity. Neuromuscular paralysis phenomena have also been described, particularly when administered together with other drugs that affect this system, such as anesthetics and muscle relaxants. These effects depend on the specific aminoglycoside being administered, the drug's blood concentration and peak level, duration of therapy, hydration status, and kidney function prior to treatment. Toxicity phenomena are rare in therapies lasting less than 7 days. Toxicity results from inhibition of phospholipid synthesis (inhibiting the incorporation of phosphate groups) and blockage of various calmodulins. Nephrotoxicosis will be preceded by an increase in blood urea nitrogen and serum creatinine, polyuria, proteinuria or cylindruria. When the eighth cranial nerve is affected, vestibular syndrome or nerve deafness may be seen, depending on the portion affected. This phenomenon can be reversible upon discontinuation of treatment. Gentamicin is highly nephrotoxic and comparatively less ototoxic. Cats are particularly sensitive to aminoglycoside-induced ototoxicity.
Contraindications:
Do not use in animals with a history of hypersensitivity to the drug or renal insufficiency. Do not mix with chloramphenicol as it antagonizes GENTAMICIN. Do not combine with other nephrotoxic agents or diuretics such as furosemide or ethacrynic acid. Do not use concomitantly with muscle relaxants or during anesthesia with halothane or methoxyflurane. Do not apply to horses intended for human consumption.
